A
fter losing weight, it is particularly difficult not resume as an increase in the sensation of hunger and food intake push the individual to resume weight, a number of adaptations of maintaining metabolic energy is put in place.Studies conducted in rodents have suggested a reduction of leptin concentrations observed during weight loss could inform the brain so that it increases food intake and decreases energy expenditure. Leptin could play a similar role in humans ?
To answer this question, a team of New York was interested in subjects who lost weight, changes in activity recorded in functional MRI functional in some brain regions and their interaction with leptin.
After losing weight and be stabilized at -10% of their initial weight, patients received injections under the skin or bi-daily leptin or placebo.
After weight loss, a number of changes in neuronal activity were observed in specific regions, especially in regions involved in emotional and cognitive control of food intake. In more specific, after weight loss, there was an increase of neuronal activity in response to visual stimuli food culmen at the para-seahorse, frontal gyrus of the middle and lower, the average temporal gyrus and gyrus lingual.
After administration of leptin, the neuronal activity decreased. The same was true of the activities observed in the hypothalamus of cingulae gyrus and middle frontal gyrus.
All these data seem to indicate that changes in neural regions of the brain involved in controlling energy homeostasis, vegetative and Hedonic are dependent on leptin and leptin in reducing by reducing weight, it implements any a series of changes leading to neuronal change in a coordinated manner, food intake and energy expenditure to promote a resumption of weight and finally fix weight loss.
Leptin appears therefore to play a role hormone protection against weight loss howsoever caused (intentionally or not) Can we imagine we can then use leptin in patients who have lost weight so as to avoid a resumption of weight ? (by Philippe Chanson)
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